Publications

  1. ASCT2 is a major contributor to serine uptake in cancer cells.

    Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solis C, Hasnain Y, Novikova A, Endress JE, Gonzalez-Sanchez P, Dong W, Stephanopoulos G, Rathmell WK, DeNicola GM, Harris IS, Sept D, Mason FM, Coloff JL.

    Cell Reports. 2024, Aug 27;43(8):114552.

  2. Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.

    Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solis C, Hasnain Y, Novikova A, Endress JE, Gonzalez-Sanchez P, Dong W, Stephanopoulos G, Rathmell WK, DeNicola GM, Harris IS, Sept D, Mason FM, Coloff JL.

    JCI Insight. 2024. May 30:e174329.

  3. Oncogenic metabolic rewiring independent of proliferative control in human mammary epithelial cells.

    Dong W, Keibler MA, Moon SJ, Cho P, Liu N, Berrios CJ, Kelleher JK, Sikes HD, Illiopoulos O, Coloff JL, Vander Heiden MG, Stephanopoulos G.

    bioRxiv. https://doi.org/10.1101/2022.04.08.486845.

  4. SOX2 Mediates Metabolic Reprogramming of Prostate Cancer Cells.

    de Wet L, Williams A, Gillard M, Kregel S, Lamperis S, Gutgesell LC, Vellky JE, Brown R, Conger K, Paner GP, Wang H, Platz EA, De Marzo AM, Mu P, Coloff JL, Szmulewitz RZ, Vander Griend DJ.

    Oncogene. 2022 Feb;41(8):1190-1202. doi: 10.1038/s41388-021-02157-x. Epub 2022 Jan 24.

  5. Lineage-Specific Silencing of PSAT1 Induces Serine Auxotrophy and Sensitivity to Dietary Serine Starvation in Luminal Breast Tumors.

    Choi BH, Rawat V, Hogstrom J, Burns PA, Conger KO, Ozgurses ME, Patel JM, Mehta TS, Warren A, Selfors LM, Muranen T, Coloff JL.

    Cell Reports. 2022. Jan 18;38(3):110278. doi: 10.1016/j.celrep.2021.110278.

  6. Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells.

    Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, Vander Heiden MG, Stephanopoulos G.

    FEBS J. 2021 Oct;288(19):5629-5649. doi: 10.1111/febs.15858. Epub 2021 May 13.

  7. PHGDH supports liver ceramide synthesis and sustains lipid homeostasis.

    Kang YP, Falzone A, Liu M, Gonzalez-Sanchez P, Choi BH, Coloff JL, Saller JJ, Karreth FL, DeNicola GM.

    Cancer & Metabolism. 2020 Jun 15;8:6. doi: 10.1186/s40170-020-00212-x. eCollection 2020.

  8. The Diverse Functions of Non-Essential Amino Acids in Cancer.

    Choi BH, Coloff JL.

    Cancers (Basel). 2019 May 15;11(5). pii: E675. doi: 10.3390/cancers11050675.

  9. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.

    Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS.

    Cell Metabolism. 2019 May 7;29(5):1166-1181.e6. doi: 10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21.

  10. Glutamate Dehydrogenase to the Rescue.

    Coloff JL.

    Molecular Cell. 2018 Jan 4;69(1):1-2. doi: 10.1016/j.molcel.2017.12.015.

  11. Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells.

    Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG.

    Elife. 2017 Dec 14;6. pii: e27293. doi: 10.7554/eLife.27293.

  12. Identification of cancer genes that are independent of dominant proliferation and lineage programs.

    Selfors LM, Stover DG, Harris IS, Brugge JS, Coloff JL.

    PNAS. 2017 Dec 26;114(52):E11276-E11284. doi: 10.1073/pnas.1714877115. Epub 2017 Dec 11.

  13. Metabolic changes promote rejection of oncogenic cells.

    Coloff JL, Brugge JS.

    Nature Cell Biology. 2017 Apr 27;19(5):414-415. doi: 10.1038/ncb3521.

  14. Starved epithelial cells uptake extracellular matrix for survival.

    Muranen T, Iwanicki MP, Curry NL, Hwang J, DuBois CD, Coloff JL, Hitchcock DS, Clish CB, Brugge JS, Kalaany NY.

    Nature Communications. 2017 Jan 10;8:13989. doi: 10.1038/ncomms13989.

  15. ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

    Muranen T, Selfors LM, Hwang J, Gallegos LL, Coloff JL, Thoreen CC, Kang SA, Sabatini DM, Mills GB, Brugge JS.

    Cancer Research. 2016 Dec 15;76(24):7168-7180. Epub 2016 Oct 20.

  16. The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression-Based Meta-Analysis.

    Stover DG, Coloff JL, Barry WT, Brugge JS, Winer EP, Selfors LM.

    Clinical Cancer Research. 2016 Dec 15;22(24):6039-6050. Epub 2016 Jun 21.

  17. Coping with the metabolic stress of leaving home.

    Coloff JL, Brugge JS.

    Cell Research. 2016 Jul;26(7):757-8. doi: 10.1038/cr.2016.61. Epub 2016 May 24.

  18. Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.

    Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS.

    Cell Metabolism. 2016 May 10;23(5):867-80. doi: 10.1016/j.cmet.2016.03.016. Epub 2016 Apr 28.

  19. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.

    Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J, Vakifahmetoglu-Norberg H.

    Journal of Cell Biology. 2015 Aug 31;210(5):705-16. doi: 10.1083/jcb.201503044.

  20. HIF1α and HIF2α exert distinct nutrient preferences in renal cells.

    Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK.

    PLoS One. 2014 May 30;9(5):e98705. doi: 10.1371/journal.pone.0098705. eCollection 2014.

  21. Combining amine metabolomics and quantitative proteomics of cancer cells using derivatization with isobaric tags.

    Murphy JP, Everley RA, Coloff JL, Gygi SP.

    Anal Chem. 2014 Apr 1;86(7):3585-93. doi: 10.1021/ac500153a. Epub 2014 Mar 20.

  22. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.

    Parkhitko AA, Priolo C, Coloff JL, Yun J, Wu JJ, Mizumura K, Xu W, Malinowska IA, Yu J, Kwiatkowski DJ, Locasale JW, Asara JM, Choi AM, Finkel T, Henske EP.

    Mol Cancer Res. 2014 Jan;12(1):48-57. doi: 10.1158/1541-7786.MCR-13-0258-T. Epub 2013 Dec 2.

  23. Chaperone-mediated autophagy degrades mutant p53.

    Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J.

    Genes Dev. 2013 Aug 1;27(15):1718-30. doi: 10.1101/gad.220897.113.

  24. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

    Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA.

    Cell. 2012 Apr 27;149(3):656-70. doi: 10.1016/j.cell.2012.01.058.

  25. Extracellular matrix regulation of metabolism and implications for tumorigenesis.

    Grassian AR, Coloff JL, Brugge JS.

    Cold Spring Harb Symp Quant Biol. 2011;76:313-24. doi: 10.1101/sqb.2011.76.010967. Epub 2011 Nov 21. Review.

  26. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.

    Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS.

    Genes Dev. 2011 Aug 15;25(16):1716-33. doi: 10.1101/gad.16771811.

  27. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.

    Coloff JL, Macintyre AN, Nichols AG, Liu T, Gallo CA, Plas DR, Rathmell JC.

    Cancer Res. 2011 Aug 1;71(15):5204-13. doi: 10.1158/0008-5472.CAN-10-4531. Epub 2011 Jun 13.

  28. Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability.

    Horn SR, Thomenius MJ, Johnson ES, Freel CD, Wu JQ, Coloff JL, Yang CS, Tang W, An J, Ilkayeva OR, Rathmell JC, Newgard CB, Kornbluth S.

    Mol Biol Cell. 2011 Apr 15;22(8):1207-16. doi: 10.1091/mbc.E10-07-0567. Epub 2011 Feb 16.

  29. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.

    Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC.

    J Biol Chem. 2011 Feb 18;286(7):5921-33. doi: 10.1074/jbc.M110.179101. Epub 2010 Dec 15.

  30. Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis.

    Altman BJ, Jacobs SR, Mason EF, Michalek RD, MacIntyre AN, Coloff JL, Ilkayeva O, Jia W, He YW, Rathmell JC.

    Oncogene. 2011 Apr 21;30(16):1855-67. doi: 10.1038/onc.2010.561. Epub 2010 Dec 13.

  31. Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl.

    Mason EF, Zhao Y, Goraksha-Hicks P, Coloff JL, Gannon H, Jones SN, Rathmell JC.

    Cancer Res. 2010 Oct 15;70(20):8066-76. doi: 10.1158/0008-5472.CAN-10-0608. Epub 2010 Sep 28.

  32. The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia.

    Ke H, Harris R, Coloff JL, Jin JY, Leshin B, Miliani de Marval P, Tao S, Rathmell JC, Hall RP, Zhang JY.

    Cancer Res. 2010 Apr 15;70(8):3080-8. doi: 10.1158/0008-5472.CAN-09-2923. Epub 2010 Mar 30.

  33. The Integration of Metabolism and Cell Death. Book Chapter.

    Coloff JL, Zhao Y, Rathmell JC.

    “Essentials of Apoptosis: A Guide for Basic and Clinical Research, 2nd ed.” 2009.

  34. Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.

    Altman BJ, Wofford JA, Zhao Y, Coloff JL, Ferguson EC, Wieman HL, Day AE, Ilkayeva O, Rathmell JC.

    Mol Biol Cell. 2009 Feb;20(4):1180-91. doi: 10.1091/mbc.E08-08-0829. Epub 2008 Dec 24.

  35. Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation.

    Zhao Y, Coloff JL, Ferguson EC, Jacobs SR, Cui K, Rathmell JC.

    J Biol Chem. 2008 Dec 26;283(52):36344-53. doi: 10.1074/jbc.M803580200. Epub 2008 Nov 6.

  36. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival.

    Maciver NJ, Jacobs SR, Wieman HL, Wofford JA, Coloff JL, Rathmell JC.

    J Leukoc Biol. 2008 Oct;84(4):949-57. doi: 10.1189/jlb.0108024. Epub 2008 Jun 24. Review.

  37. Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.

    Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC.

    Mol Cell Biol. 2007 Jun;27(12):4328-39. Epub 2007 Mar 19.

  38. Metabolic regulation of Akt: roles reversed.

    Coloff JL, Rathmell JC.

    J Cell Biol. 2006 Dec 18;175(6):845-7. Epub 2006 Dec 11.

  39. Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras.

    Baker TL, Zheng H, Walker J, Coloff JL, Buss JE.

    J Biol Chem. 2003 May 23;278(21):19292-300. Epub 2003 Mar 17.